Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis

Background: Osteoclasts are bone-resorbing multinuclear polykaryons essential for bone remodeling, formed through cell fusion of mononuclear macrophage/monocyte lineage precursor cells upon stimulation by the Dining RANK/RANKL system.Recent studies have revealed that a family of tetraspanin proteins, such as CD9, is critically involved in the cell

read more



Local inflammation, dissemination and coalescence of lesions are key for the progression towards active tuberculosis: the bubble model

The evolution of a tuberculosis (TB) infection towards active disease is driven by a combination of factors mostly related to the host response.The equilibrium between control of the bacillary load and the Purple Conditoner pathology generated is crucial as regards preventing the growth and proliferation of TB lesions.In addition, some experimental

read more